Treatment of IDH-mutant glioma in the INDIGO era

Treatment of IDH-mutant glioma in the INDIGO era

Blog Article

Abstract Gliomas are the most common primary brain tumor and are uniformly lethal.Despite significant advancements in understanding the genetic landscape of gliomas, Analytically Computing the Moments of a Conic Combination of Independent Noncentral Chi-Square Random Variables and Its Application for the Extended Cox–Ingersoll–Ross Process with Time-Varying Dimension standard-of-care has remained largely unchanged.Subsets of gliomas are defined by gain-of-function mutations in the metabolic genes encoding isocitrate dehydrogenase (IDH).Efforts to exploit mutant IDH activity and/or directly inhibit it with mutant IDH inhibitors have been the focus of over a decade of research.The recently published INDIGO trial, demonstrating the benefit of the mutant IDH inhibitor vorasidenib in patients with low-grade IDH-mutant gliomas, introduces a new era of precision medicine in brain tumors that is poised to change standard-of-care.

In this review, Regional, subregional and country-level full vaccination coverage in children aged 12–23 months for 34 countries in sub-Saharan Africa: a global analysis using Demographic and Health Survey data we highlight and contextualize the results of the INDIGO trial and introduce key questions whose answers will guide how mutant IDH inhibitors may be used in the clinic.We discuss possible combination therapies with mutant IDH inhibition and future directions for clinical and translational research.